Action
Thrombolytic

Status
US FDA approved in acute ischemic stroke within 3 hours of onset, June 1996. Study of tPA with stroke onset 3-5 hours (ATLANTIS) halted 7/98 due to lack of efficacy.

Trial(s)
  = Ongoing
  = Completed

		Abciximab and rt-PA in Acute Ischemic Stroke Treatment
	ALIAS - Pilot	Albumin in Acute Stroke
	ARTIS	Antiplatelet therapy in combination with Recombinant t-PA Thrombolysis in Ischemic Stroke.
	ARTIST +	AMPA Receptor Antagonist Treatment in Ischemic Stroke Trial
	ATLANTIS	Alteplase ThromboLysis for Acute Noninterventional Therapy in Ischemic Stroke
	ATTRACT	Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis
	CASES	Canadian Activase for Stroke Effectiveness Study
	CLEAR IVH	Evaluating Accelerated Resolution of Intraventricular Hemorrhage, rt-PA (Cathflo®) Treatment of Brain Hemorrhage
	CLEAR	Combined Approach to Lysis Utilizing Eptifibatide and rt-PA in Acute Ischemic Stroke [SPOTRIAS]
	CLEAR-ER	Study of the Combination Therapy of rt-PA and Eptifibatide to Treat Acute Ischemic Stroke[SPOTRIAS].
		Clinical importance of microbleeds in patients receiving IV thrombolysis
	CLOTBUST Phase I	Combined Lysis of Thrombus in Brain ischemia with Transcranial Ultrasound and Systemic TPA [SPOTRIAS]
	CLOTBUST Phase II	Combined Lysis of Thrombus in Brain Ischemia with Transcranial Ultrasound and Systemic TPA [SPOTRIAS]
	CLOTBUSTER	A Randomized, Active Controlled, Double-Blinded Trial of the Combined Lysis of Thrombus With Ultrasound, Microspheres and Systemic Tissue Plasminogen Activator (tPA) for Emergent Revascularization (CLOTBUSTER) in Acute Ischemic Stroke
	COAST-II	Cooling in acute Stroke-II
		Comparison of Intra-arterial and Intravenous Thrombolysis for Ischemic Stroke with Hyperdense Middle Cerebral Artery Sign
	DEFUSE	Diffusion-weighted Imaging Evaluation For Understanding Stroke Evolution
	DITCH	Dutch Intraventricular Thrombolysis after Cerebral Hemorrhage study
	ECASS-I	European Cooperative Acute Stroke Study
	ECASS-II	European and Australian Cooperative Stroke Study II
	ECASS-III	ECASS-III: Placebo controlled trial of alteplase (rt-PA) in acute ischemic hemispheric stroke where thrombolysis is initiated between 3 and 4 hours after stroke onset
	EMS	Emergency Management of Stroke Bridging Trial
	EPITHET - Pilot	Echoplanar Imaging Thrombolysis Evaluation - Pilot Study
	EPITHET	Echoplanar Imaging Thrombolysis Evaluation Trial
	EXTEND	Extending the Time for Thrombolysis in Emergency Neurological Deficits
	ICTuS-L	Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke [SPOTRIAS]
	IMS - II	Interventional Management of Stroke Study
	IMS - III	The Interventional Management of Stroke (IMS) III Trial
	IMS	Interventional Management of Stroke Study
		Intraoperative, intracisternal tissue plasminogen activator for the prevention of vasospasm
	IST-3	Third International Stroke Trial
	ITAIS-II	Imaging-based Thrombolysis trial in Acute Ischemic Stroke-II
	ITAIS	Imaging-based Thrombolysis Trial in Acute Ischemic Stroke
	ITT	Intraventricular Hemorrhage Thrombolysis Trial
	MAGIC	BIOLOGICAL MARKERS AS PREDICTORS OF CLINICAL-FUNCTIONAL OUTCOME AND RESPONSE TO REVASCULARIZATION STRATEGIES IN ACUTE ISCHEMIC STROKE
	Multi MERCI	Mechanical Embolus Removal in Cerebral Ischemia
	NINDS-tPA	NINDS t-PA Stroke Trial
		Perfusion-CT guided intravenous thrombolysis at 3 to 6 hours: feasibility and safety study
		Pilot randomized trial of tissue plasminogen activator in acute ischemic stroke
		Prevention of delayed ischemic deficits after aneurysmal subarachnoid hemorrhage by intrathecal bolus injection of tissue plasminogen activator
		Safety and Efficacy of MRI-Based Thrombolysis in Unclear-Onset Stroke
	SITS-ISTR	Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Register
	SITS-MOST	Safe Implementation of Thrombolysis in Stroke Monitoring Study
	SLEUTH	Safety of Lysis with EKOS Ultrasound in the Treatment of Intracerebral and Intraventricular Hemorrhage
	STARS	Standard Treatment with Alteplase to Reverse Stroke study
	START-EXTEND	STroke imAging pRevention and Treatment-Extending the time for Thrombolysis in Emergency Neurological Deficits
		Study of Aspirin and TPA in Acute Ischemic Stroke
		Study of Tenecteplase (TNK) in Acute Ischemic Stroke (TNK-S2B)[SPOTRIAS]
	TARTS	Argatroban tPA Stroke Study [SPOTRIAS]
	TELESTROKE	TRUST_tPA: Therapeutic Trial Evaluating Efficacy of Telemedicine (TELESTROKE) of Patients With Acute Stroke
	TESPI	Thrombolysis in Elderly Stroke Patients in Italy
	TRUMBI	Transcranial Low-Frequency Ultrasound Mediated Thrombolysis in Brain Ischemia Study
	TRUST	Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion
	TTAISS	Thrombolytic Therapy in Acute Ischemic Stroke Study, Part A
		Urokinase versus r-TPA in Stroke Patients

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