Stroke Trials Registry

Pentoxifylline
Trental® Oxpentifylline

Action
Vasodilator. In addition, may reduce viscosity or improve erythrocyte flexibility.

Status
FDA approved for intermittent claudication, peripheral vascular disease. No known development for stroke or TIA.

Trial(s)
= Ongoing
= Completed

Pentoxifylline and antiaggregants in recent transient ischemic attacks

Pentoxifylline in Acute Nonhemorrhagic Stroke

Pentoxifylline versus conventional antiaggregants in secondary stroke prevention

Web Links and Publications

Pentoxifylline Patient Information (MEDLINE plus).

Aventis Web Site.

Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke.
Cochrane Database Systematic Review. 2000;2:CD000162.

The effect of pentoxifylline on treatment results and course of rehabilitation of patients after ischemic stroke.
Pol Merkuriusz Lek. 1998 Mar;4(21):116-8. [Polish.]

Vascular dementia Italian sulodexide study (VA.D.I.S.S.). Clinical and biological results.
Thromb Res 1997 Jul 15;87(2):225-33

European Pentoxifylline Multi-Infarct Dementia Study.
Eur Neurol 1996;36(5):315-21

Pentoxifylline in the treatment of acute ischaemic stroke--a reappraisal in Chinese stroke patients.
Clin Exp Neurol 1993;30:110-6

Hemorheologic treatment of cerebral reversible ischemic episodes with pentoxifylline--a prospective study.
Angiology 1988 Jun;39(6):520-5

A randomized clinical trial of pentoxifylline and antiaggregants in recent transient ischemic attacks (TIA). A one year follow-up.
Ric Clin Lab 1981;11 Suppl 1:257-64.

Randomised trial of pentoxifylline versus acetylsalicylic acid plus dipyridamole in preventing transient ischaemic attacks.
Lancet 1981 May 2;1(8227):966-8

UID: 63